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Staff photo Paulina Wanrooij

Paulina Wanrooij

I lead a research group that focuses on mitochondrial DNA and the molecular mechanisms that mediate the signaling of its instability.

 

Research qualifications: Docent

Contact

E-mail
paulina.wanrooij@umu.se
Phone

Works as

Affiliation
Research fellow at Department of Medical Biochemistry and Biophysics
Location
KB. H6, Campus, dg club dg club, 901 87 dg club

Our cells contain genetic information in two separate compartments - the nucleus and the mitochondria. Mitochondrial DNA (mtDNA) is a small circular double-stranded DNA molecule that contains information that is essential for efficient energy production. Problems with mitochondrial DNA can therefore lead to a cellular energy defect and mitochondrial disease.

My group works on various aspects of mitochondrial DNA stability, and on how problems with mitochondrial DNA are signalled to the rest of the cell. A thorough understanding of the molecular mechanisms that mediate these signals relates to various hereditary mitochondrial diseases, but also to neurodegenerative disease and various types of cancers.

Read more about our research on

Molecular Biology of the Cell, American Society for Cell Biology (ASCB) 2025, Vol. 36, (2)
Aasumets, Koit; Hangas, Anu; Fragkoulis, Georgios; et al.
Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences (PNAS) 2025, Vol. 122, (16)
Awoyomi, Ololade Folajimi; Gorospe, Choco Michael; Das, Biswajit; et al.
The FEBS Journal
Carvalho, Gustavo; Nguyen, Tran V. H.; Repolês, Bruno Marçal; et al.
Life Science Alliance, Life Science Alliance 2024, Vol. 7, (8)
Breidenstein, Annika; Lamy, Anaïs; Bader P.J., Cyrielle; et al.
Life Science Alliance, Life Science Alliance, LLC 2023, Vol. 6, (12)
Gorospe, Choco Michael; Carvalho, Gustavo; Herrera Curbelo, Alicia; et al.
Mitochondrial DNA: methods and protocols, New York: Humana Press 2023 : 293-314
Gorospe, Choco Michael; Repolês, Bruno Marçal; Wanrooij, Paulina H.
EMBO Journal, John Wiley & Sons 2023, Vol. 42, (18)
Wanrooij, Paulina H.; Chabes, Andrei
Antioxidants and Redox Signaling, Mary Ann Liebert 2022, Vol. 36, (13-15) : 885-905
Carvalho, Gustavo; Repolês, Bruno Marçal; Mendes, Isabela; et al.
Mitochondrion (Amsterdam. Print), Elsevier 2021, Vol. 61 : 179-187
Repolês, Bruno Marçal; Gorospe, Choco Michael; Tran, Phong; et al.
The human mitochondrial genome: from basic biology to disease, Academic Press 2020 : 3-33
Doimo, Mara; Pfeiffer, Annika; Wanrooij, Paulina H.; et al.
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2020, Vol. 117, (25) : 14306-14313
Wanrooij, Paulina H.; Tran, Phong; Thompson, Liam J.; et al.
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2019, Vol. 394, (44) : 15889-15897
Tran, Phong; Wanrooij, Paulina H.; Lorenzon, Paolo; et al.
FEBS Letters, John Wiley & Sons 2019, Vol. 593, (13) : 1554-1565
Wanrooij, Paulina H.; Chabes, Andrei
PLOS Genetics, Public library science 2018, Vol. 14, (3)
Forslund, Josefin M. E.; Pfeiffer, Annika; Stojkovič, Gorazd; et al.
Journal of Virology, American Society for Microbiology 2018, Vol. 92, (19)
Nystrom, Kristina; Wanrooij, Paulina H.; Waldenstrom, Jesper; et al.
International Journal of Molecular Sciences, MDPI AG 2017, Vol. 18, (7)
Boldinova, Elizaveta O.; Wanrooij, Paulina H.; Shilkin, Evgeniy S.; et al.
Journal of Hepatology, ELSEVIER SCIENCE BV 2017, Vol. 66, (1) : S321-S321
Nystrom, K.; Pettersson, G.; Wanrooij, Paulina; et al.
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2017, Vol. 114, (47) : 12466-12471
Wanrooij, Paulina H.; Engqvist, Martin K. M.; Forslund, Josefin M. E.; et al.
Journal of Biological Chemistry, Elsevier 2016, Vol. 291, (26) : 13436-13447
Sawicka, Marta; Wanrooij, Paulina H.; Darbari, Vidya C.; et al.
Scientific Reports, Vol. 6
Stojkovic, Gorazd; Makarova, Alena V.; Wanrooij, Paulina H.; et al.
Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides
Journal of Biological Chemistry, Vol. 291, (1) : 393-401
Wanrooij, Paulina H.; Tannous, Elias; Kumar, Sandeep; et al.

Research groups

Head of research
Paulina Wanrooij lab

Research projects

1 January 2020 until 31 December 2022
Checkpoint mechanisms that safeguard the mitochondrial genome